Here's an excellent video from GradIreland TV featuring Tom Bentley of SAP who is speaking about the recruitment process and what graduates should do when applying for jobs. It's aimed at IT graduates, but much of what he says can be applied to job applications in general.
One quote from the talk that I really liked was "Every time you apply for a job, change your CV". Bentley states clearly that each job is different and he gives some examples of how and why you would change your CV depending on the job you are applying for. The video is nearly 14 minutes long, but worth watching the lot if you are looking for a job in IT.